They might talk about wanting to die or make plans for taking their life.
In its Vital Signs report, the CDC said that almost 45,000 Americans died by their own hand in 2016.
"Research for many years and across social and health science fields has demonstrated a strong relationship between economic downturns and an increase in deaths due to suicide", Sarah Burgard an associate professor of sociology at the University of MI, explained in an email on Thursday.
Take the person to an emergency room or seek help from a medical or mental health professional. During that time, the suicide rate went up 13 percent.
The 2nd Floor youth helpline confidentially serves youth and young adults ages 10-24, who have an issue or problem: 1-888-222-2228, or text at 888-222-2228.
"We want people to know they can talk to us and we can help them find healthy alternatives", he said.
The report is bad news, the CDC acknowledges, but people are not helpless to prevent suicide.
Patrick Smith, CEO of the Canadian Mental Health Association in Toronto, said he isn't aware of a similar increase among that age group in Canada.
"The reason most suicide decedents don't have a known mental disorder is that they were never diagnosed, not that they didn't have one", said Dr. David Brent, a professor of psychiatry at the University of Pittsburg.More news: Top North Korean official, Pompeo meet to discuss summit
Julia Payson says it's important to let people know you're there for them.
Laura Marx of the Capital Region chapter of the American Foundation of Suicide Prevention says solving the problem starts with knowing the warning signs. "We do have higher rates of suicide in Colorado".
Between 2007 to 2012, there were dramatic cuts to mental health funding.
Suicide is increasing among all demographics, but there was a 43 percent increase in deaths of men aged 45-64 between 1999 and 2016, according to the CDC. Habitual users of opioids were twice as likely to attempt suicide as people who did not use them.
Rates of increase varied.
The most recent suicide rates, taken from data between 2014 and 2016, ranged from 6.9 per 100,000 residents in Washington, D.C., to 29.2 per 100,000 residents in Montana.
"Just to sit with someone when they're in a crisis and they know you get it".
"We have to keep working on stigma", Zietlow-DeJesus said.
If you or someone you love needs help, the National Suicide Prevention hotline is 1-800-273-TALK (8255) or text "talk" to 741741.
Heather Brown is a suicide prevention expert with Maricopa County.