With 12 assists and nine goals in the league alone, the German winger is on course to register double figures in both by the time the season comes to a close.
The victor will be announced at the PFA's annual awards ceremony in London on Sunday, April 22.
Click through the gallery to see the six nominees for the award.
De Bruyne struggled to have an impact on the Champions League tie as the Citizens lost to Liverpool FC for a third time this season.
So it was no surprise when the pair were named amongst the six nominees for PFA Player of the Year.More news: Real Madrid's Sergio Ramos could be banned for Champions League semi-final
The Spain playmaker has eight goals and 11 assists to his name in a City team which has dominated the competition this year.
Kane may have gotten plenty of stick from opposition fans for claiming one for the dubious goals this week, but the Spurs frontman has still had a supremely productive season.
Salah is now on track as he leads the top scorers list of the PL with 29 goals, with a wide gap between him and Harry Kane who has four goals. He's now leading the Golden Boot race, four goals clear of second-placed Kane.
Meanwhile, Marcus Rashford has a place on the shortlist for the PFA Young Player of the Year trophy as the 20-year-old continues his excellent form for United and England.
Ederson, 24, is second in the league behind De Gea with 15 clean sheets and has helped City put together the league's best defensive record through 32 games.