The North Londoners made it to this stage of the competition, after beating AFC Wimbledon 3-0 at the Wembley Stadium.
They remain unbeaten in their last six matches and that form has pushed Michael Flynn's troops into eighth in the League Two table.
The last time Tottenham lost to fourth-tier opposition was when they faced Russell Slade's Grimsby Town in September 2005.
Mauricio Pochettino will be looking to rotate his squad ahead (Picture: AFP/Getty Images)What TV channel is Newport vs Tottenham on? Joss Labadie and Matthew Dolan are not certainties for this tie.
Newport keeper Day was later helpless when Son's flick fell to Kane to score from close range
Fernando Llorente and Harry Kane are up top for Spurs.
Victor Wanyama, who did not feature in the weekend game, should start in the middle of the park, alongside Eric Dier to provide a solid platform for the attack-minded players to build upon.
Tottenham have won by at least three clear goals in four of their last five victories and the 11/10 (2.10) quote for Spurs (-2) in the handicap market could well represent good value.
"We are in that process that one training session is important, one game against Real Madrid or Manchester United".
The London Evening Standard claim on their website that the Belgian worldwide will not play any part in Spurs' FA Cup tie against the League Two side with manager Mauricio Pochettino choosing not to risk him after his long term absence through injury.More news: Trump proposes path to citizenship for 1.8 million