DCSO was involved in a pursuit following an attempted felony stop. Of the five deputies wounded, one died.
Two other people at the apartment complex were also shot in the incident, and the suspect is dead, police said.
"Deputies responded to a domestic disturbance resulting in shots fired", the sheriff's office said in the post. "We are not giving numbers or status at this point, we are still working on getting the suspect in custody".
The Douglas County Sheriff's Office also confirmed that the gunman was shot, and believed to be dead.
The sheriff's office said that the suspect knew police were coming and began firing when they arrived. Authorities say one deputy on the scene was killed and four others have been injured.More news: 'Aggressive US rhetoric' on North Korea unacceptable, Russian FM Lavrov says
The apartment complex is 16 miles south of Denver, The Associated Press reports.
The medical condition of the surviving deputies and the nature of their injuries were not immediately known.
As the incident unfurled, the sheriff's office advised local residents to take cover in place and stay away from windows.
Law enforcement agencies including the Parker Police Department, the Lone Tree Police Department, the Castle Rock Police Department and the Colorado State Patrol were lending assistance, they added in a tweet.