The Pope's words came ahead of an expected announcement by U.S. President Donald Trump to recognize Jerusalem as Israel's capital city by establishing the American embassy to Israel there.
Trump is expected to recognize Jerusalem as the capital of Israel on Wednesday and begin the process of relocating the U.S. Embassy from Tel Aviv to Jerusalem.
Describing the city as "holy for Jews, Christians and Muslims, who venerate the holy sites of their respective religions", the Pope said Jerusalem enjoys a unique status that should be preserved.
Palestinian leader Mahmoud Abbas said it would mark the end of years of peace efforts and have "dangerous consequences" for the "security and stability of the region and of the world".
"At the same time, I would like to make a heartfelt appeal for everyone's commitment to respect the city's status quo, in conformity with the pertinent United Nations resolutions", Pope Francis said to his weekly general audience.
"The US president and his regional allies will bear responsibility for this decision's unsafe consequences", the official said.
Trump stated, on Tuesday, that the United States will recognize Jerusalem as the capital of Israel, but did not mention whether the Middle Eastern country's US embassy would be moved from Tel Aviv to the "new" lead city. numerous speculative reports suggest that the American head of state will establish Jerusalem's only embassy.
He appealed "that eveyrone respects the status quo of the city", according to United Nations resolutions.
Palestinians insist there is no hope of a peace agreement unless they can use the east of the city as their capital, but the Israelis claim the whole city as their own.
Saudi Arabia's King Salman warned his close ally that moving the U.S. embassy was a "dangerous step" that could rile Muslims around the world.
Dialogue, the pope said, takes place at every level, especially "in our families, in our religious communities, between different religious communities, and also in civil society".
In his remarks, Pope Francis said the Holy Land was the "land par excellence of dialogue between God and mankind".More news: ESPN's Herm Edwards introduced as Arizona State coach