The Cyclones improved to 3-2, while the Sooners fell to 4-1 and saw their College Football Playoff hopes suffer a significant setback.
Iowa State coach Matt Campbell is not certain of a timeline for Park's return, and said he can not discuss issue.
Folks in Ames were excited to see the progression of the Cyclones program the day Campbell was handed the keys to the vehicle, and after toppling the Sooners on Saturday, there's even more of a reason to be excited about what's happening with Iowa State.More news: Trump administration rolls back birth control coverage under ACA
Ohio State fans remember Oklahoma quarterback Baker Mayfield planting a flag at midfield after the Sooners' 31-16 win at Ohio Stadium earlier this season. The Cyclones took the lead for good on Kyle Kempt's 25-yard touchdown pass to Allen Lazard with 2 minutes, 19 seconds remaining. Oklahoma RBs Abdul Adams and Trey Sermon have emerged as threats in Oklahoma's No. 1-ranked offense, but they face an Iowa State defense that allowed just 141 yards rushing on 52 carries against Texas last week. The first- and second-place teams will meet on December 2 in Arlington, Tex.
Iowa State starting quarterback Jacob Park is taking a leave of absence because of unspecified "personal health issues", the team announced Friday night.
"Jacob is a great young man dealing with some personal medical concerns", Iowa State coach Matt Campbell said in a prepared statement. Kempt appeared in one game for the Cyclones last season and completed both of his passes.