An Unprecedented Study Has Revealed 72 New Breast Cancer Gene Variants

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"Information on these variants could be combined with other strong breast cancer risk factors, such as age, family history and mammographic density to provide more precise estimates of risk", said Associate Professor Roger Milne, epidemiology director of Cancer Council Victoria.

After studying 122,977 cases of ER-positive cases, researchers can explain an additional 4 percent of that heritable breast cancer risk.

Sheryl Crow is a Grammy Award-winning musician and breast cancer survivor who is passionate about spreading the message of early detection.

By comparing the genes of those diagnosed with the condition with those who had no history of breast cancer, the researchers were able to identify 65 variations of genes that contributed to the disease's development.

Two genes already commonly associated with breast cancer are BRCA1 and BRCA2. The researchers found that non-cancerous breast tissue had more of a certain type of bacteria, and the cancerous tissue had other types that were elevated. In total, they analysed genetic data from 275,000 women, of whom 146,000 had been diagnosed with breast cancer.

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'As well as identifying new genetic variants, we have also confirmed many that we had previously suspected. "Our Making Strides Against Breast Cancer walk ensures no one faces breast cancer alone by bringing the community together, funding innovative breast cancer research, promoting education and risk reduction, and providing comprehensive patient support to those who need it most".

Others, known as oestrogen-receptor negative, are not affected by the hormone and are more hard to treat. "That is when it is curable and we have more treatment options if found early", McCain said.

By analysing the 180 regions of the genome where are located some of the variations that predispose to breast cancer, it will be possible to determine the risk of a woman developing this cancer. Combining the genetic factors with hormonal and lifestyle influences was likely to increase the risk further, they said. She hopes that discoveries made in this research will someday lead to better and less harsh treatments for breast cancer, for instance, treating people with a targeted probiotic instead of chemotherapy.

'These gene changes now have the potential to be incorporated into existing models to more accurately predict an individual's risk, and to improve both prevention and early detection of the disease. "If a test is developed and a woman finds out she is at high risk, what steps are in place for her to take action in reducing that risk?" she told The New Daily.