As an outsider, I expect the world no 84, Sloane Stephens to have a great US Open.
"I did pretty much everything that I could to get myself ready here and took a number of weeks off after Wimbledon", he said.
"I spoke to a lot of hip specialists".
The U.S. Open is located, every year, at USTA Billie Jean King National Tennis Center which is located in Queens, New York.
The three-times grand slam victor, who won the U.S. Open in 2012, has been struggling with the injury for much of the summer. Zverev has had a fine summer, including a win against Federer in the Montreal singles final this month.
The world No 2's withdrawal is the latest in a remarkable series of physical setbacks suffered by some of the game's top players.More news: Rotherham pupils celebrate top GCSE results despite exam changes
His fellow countryman Stanislas Wawrinka (left knee), reigning champion, and the Serbian Novak Djokovic (right elbow), finalist in 2016, have put an end to their season, just like the Japanese Kei Nishikori (right wrist).
Bolstering each man's hope of another U.S. Open title is the absences of several of the tour's top players.
"On the court I'm just lacking a little bit of that consistency point after point, to be continuing with my aggression. But I'd love to play Rafa here in New York", he said.
The US Open has been an extremely happy hunting ground for the Swiss in the past, having taken the title five year in a row in the mid-2000's.
The US Tennis Open is the last tennis major of the year and, at least on the men's side, it appears to be a real war of attrition with a number of highly ranked players not making it to the starting line. They will not meet in the final this year, as they are both in the top half, and would meet in the semis if all goes well. While the women's brackets have been insane with top player Serena Williams out since the spring due to her pregnancy, it has been mostly the Roger Federer show on the men's side.
"But obviously I'll need to make the correct decision and really think it through these next couple of days with my team, and then make that decision".
Federer, meanwhile, is looking to move beyond Pete Sampras and Jimmy Connors by claiming a sixth US Open and reach a first final in the city since his sensational 2009 loss to Juan Martin del Potro. After the hard first round, Halep would have an open event until the quarterfinals, where she could meet Great Britain's Johanna Konta. It is very unlikely to have at least four players now ranked in the top ten missing the same Grand Slam tournament.