Stones scored a first half header but Gabriel Jesus and Sergio Aguero wasted several chances before Raheem Sterling and Brahim Diaz wrapped it up late on.
"Claudio is a captain of a national team who never used to win anything special, and I know how important he was in the two Copa Americas and the final of the Confederations Cup", he said.
"When I was at Bayern Munich we played Benfica in the Champions League and Ederson was there". It's pre-season, but we didn't have a performance like that last season. Adding to their woe was a miserable set of performances on their USA tour.
"I think Kelechi is going to leave, for Leicester", Guardiola told Sky Sports.
Guardiola also praised the performances of new signings Kyle Walker and Danilo, after they impressed in wing-back roles.More news: Three Israelis stabbed to death in West Bank settlement: army
This month, England right-back Kyle Walker moved from Spurs for £45m, Brazil worldwide Danilo joined from Real Madrid for £26.5m and France left-back Benjamin Mendy was recruited from Monaco for £52m.
Tottenham manager Mauricio Pochettino admitted his team are a bit behind City in their preparations but revealed that the club is working on bringing in fresh blood. That's a decision they have to take with their [agents].
"No-one wants to lose but we don't have to look to the result, we have to get better and work hard".
"We tried to work about that because he has this quality to put the ball in the other box and it's not offside". "We lost and deserved to lose".
Spurs fell behind when Stones nodded in Kevin de Bruyne's deflected free-kick after 10 minutes in Nashville, USA.