Paul Nuttall embarrassed himself while being attacked by the other leaders as he accidentally called the Plaid Cymru leader "Natalie" - only for her to reply, "I'm not Natalie, I'm Leanne".
The event will see Liberal Democrat leader Tim Farron, Ukip's Paul Nuttall and the SNP's Nicola Sturgeon lock horns.
Mr Nuttall unwittingly drew laughs from the studio audience when he addressed Ms Wood as "Natalie" not once but twice, perhaps confusing her with the former Green leader Natalie Bennett.
Green co-leader Caroline Lucas joined in, laughing and implying Nuttall had problems remembering different women's names.
The two-hour ITV debate would have been the only opportunity for voters to see the leaders of all seven major political parties go head to head live on television.
Ms Sturgeon described him as a "spokesperson" for the Prime Minister, and Ms Lucas proposed all the minor parties working together - but explicitly excluded Ukip.More news: HSE aiming to reconnect internal IT network after cyber scare
Both Farron and Lucas believe people should get the chance to vote in another European Union referendum. "Without Theresa May or Jeremy Corbyn the debate lacked real goal", it says. "I don't believe that she will get the best deal possible for Britain, I believe she will begin to backslide", he said.
The most notable thing about this debate is that Conservative leader Theresa May has said that she does not plan to do it, so chance are we might have at least one empty seat.
And he added: "Brexit would never have happened if it wasn't for UKIP!" Making a play on the Tory's "strong and stable" election mantra, she accused the Prime Minister of "weak and unstable" leadership. You want this election to only be about Brexit because that means you avoid talking about the real issues like the NHS, the economy and the cuts you have made to our public services.
This is how Wood, Lucas and SNP leader Nicola Sturgeon reacted following the second blunder.
The Ukip leader insisted last week that his party will not challenge key Tory candidates in the General Election campaign, and was humiliated as he struggled to slap down Mrs May's Brexit in order to promote his own party's policies.